Research area

Longevity research peptides

Mitochondrial, telomeric, senolytic and thymic sequences — the nine compounds Amino Club supplies for ageing-biology research, and what each one actually targets.

Four distinct targets

Longevity research peptides is a label that covers several unrelated hypotheses about ageing, and the compounds in this group map onto four of them.

The mitochondrial arm is the best represented. MOTS-C is a sixteen-residue peptide encoded in mitochondrial DNA rather than the nuclear genome, studied for AMPK-linked metabolic signalling. SS-31 is a cardiolipin-binding tetrapeptide investigated for inner-membrane stabilisation and electron transport efficiency. NAD+ is the redox cofactor itself, central to sirtuin and PARP activity, and is also supplied as a metered intranasal preparation.

The telomeric and pineal arm holds Epithalon, a synthetic tetrapeptide studied for telomerase expression and pineal regulation, and Pinealon, a short peptide investigated for neuronal effects in the same tradition.

Senolytics are represented by FOXO4-DRI, a d-retro-inverso peptide designed to disrupt the FOXO4-p53 interaction that keeps senescent cells alive. Thymic signalling is covered by Thymalin and Thymosin Alpha-1, both studied in the context of immune ageing.

Why the distinctions matter

These four mechanisms are not different routes to the same endpoint. A mitochondrial cofactor, a telomerase modulator, a senolytic and a thymic peptide are testing genuinely different propositions about why tissues age, and results in one arm say very little about the others. Study designs that treat them as interchangeable tend to produce findings that do not replicate.

The group also spans an unusually wide size range, from the four-residue Epithalon to the twenty-eight-residue Thymosin Alpha-1, which matters for solubility, adsorption and storage far more than it does in a more homogeneous group. Current strengths are on the longevity category page.

Purity, presentation and handling

Each compound is specified at 99% purity or better by HPLC with mass spectrometric identity confirmation, released against the Certificate of Analysis for its own batch, and the certificate carries the batch number printed on the vial. The lab testing page sets out the process.

NAD+ is the outlier in this group for handling: it is hygroscopic and degrades in aqueous solution considerably faster than the peptide sequences alongside it, so results depend heavily on how recently the working solution was prepared. Per-compound notes are on the individual product pages. Reconstitution consumables are under lab supplies.

Compound guides in this group

Individual guides to the compounds in this group.

Epithalon — a four-residue bioregulator from the Russian pineal programme.
NAD+ — the cofactor at the centre of the sirtuin literature.
MOTS-c — a peptide encoded in mitochondrial DNA, not in the nucleus.
SS-31 — a tetrapeptide that binds a phospholipid rather than a protein.
FOXO4-DRI — a decoy that releases p53 in senescent cells.
Thymosin Alpha-1 — a defined thymic peptide with regulatory approval behind its mechanism.
Thymalin — a thymic preparation rather than a molecule.
Pinealon — three residues, proposed to act on DNA rather than a receptor.

Research use only

All longevity research peptides listed here are laboratory reference materials. They are not medicines, not supplements, and not for human or veterinary use, and no dosing guidance or administration protocol is provided for any of them. The full terms are in the research use policy.