Home / Research library / Pinealon
Compound guide
Pinealon: what the research covers
Three amino acids, proposed to work by binding DNA rather than a receptor. It is the clearest example in this catalogue of the short peptide bioregulator idea.
What Pinealon is
Pinealon is Glu-Asp-Arg, a tripeptide. Its name refers to the pineal gland, from whose peptide fraction the sequence was identified in the Russian research programme that also produced Epithalon and Thymalin.
The proposed mechanism is what makes it unusual. Rather than binding a receptor, short peptide bioregulators are hypothesised to enter the cell and the nucleus and to interact directly with specific sequences in promoter regions of DNA, influencing transcription. The argument rests on the complementarity between certain amino acid side chains and particular bases, and on reported binding of short peptides to defined DNA sequences.
Whether that mechanism is correct is not settled outside the group that proposed it, and a reader should treat it as a hypothesis with supporting experiments rather than as established pharmacology.
What is reported, and how firm it is
Published work on Pinealon covers neuroprotection in hypoxia and ischaemia models, antioxidant readouts, effects on apoptosis in neuronal culture, and behavioural measures in aged or stressed animals. Several of those reports come from the originating programme, which is a limitation of the evidence base rather than a criticism of the work.
What is missing is independent replication at scale and any clinical trial literature in the modern sense. A laboratory considering Pinealon is considering a compound whose interest lies substantially in the mechanism it would demonstrate if the mechanism holds — direct peptide regulation of transcription — and that is a reason to work on it carefully rather than a reason to accept the claims.
A practical note on the chemistry: at three residues, two of them acidic, this is a very small and highly charged molecule, which has implications for how it would have to cross membranes for the proposed mechanism to operate at all. That question is itself worth examining.
How Amino Club supplies it
Supplied lyophilised in sealed vials as Pinealon, specified at 99% purity or better by HPLC with identity confirmed by mass spectrometry and released against the Certificate of Analysis for its own batch, as documented on the lab testing page.
Short highly charged peptides are robust as dry powders and in solution relative to longer sequences, so handling is undemanding: the sealed vial is stored below −18 °C and solutions are prepared fresh. Purity carries extra weight at this size, because a given percentage of impurity represents a larger molar fraction than it would in a long peptide. Diluents are under reconstitution supplies.
Related reading
Pinealon sits in the longevity research peptides group with Epithalon, Thymalin, Thymosin Alpha-1, NAD+, MOTS-c, SS-31 and FOXO4-DRI. Epithalon is the closest comparison, since it comes from the same programme and the same hypothesis.
Every guide is indexed in the research library. Certificates and storage are covered on the FAQ, quantity pricing through bulk and wholesale.
Research use only
Pinealon supplied by Amino Club is a laboratory reference material. It is not a medicine, not a supplement, and not for human or veterinary use, and no dosing guidance or administration protocol is provided. The full terms are in the research use policy.