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Compound guide
Ipamorelin: what the research covers
A pentapeptide ghrelin receptor agonist, studied because it is the most selective of the secretagogues rather than the most potent. What that selectivity means in practice.
What Ipamorelin is
Ipamorelin is a synthetic pentapeptide — Aib-His-D-2-Nal-D-Phe-Lys-NH2 — that acts as an agonist at the growth hormone secretagogue receptor, GHSR-1a. That is the receptor for ghrelin, and it is a different target from the GHRH receptor that CJC-1295 and Sermorelin act on.
Its significance in the literature rests on selectivity. The earlier secretagogues of this class — GHRP-2 and Hexarelin — produce measurable increases in cortisol, prolactin and ACTH alongside growth hormone release. Ipamorelin was developed specifically to reduce that cross-activity, and at research concentrations it produces substantially less of it. It is less potent as a releaser than either, and that trade-off is the entire point of the compound.
Why selectivity matters to a study design
A compound that raises cortisol alongside growth hormone confounds any endpoint that cortisol also affects — which is a long list, covering metabolic, immune and behavioural readouts. In a study attempting to attribute an observation to growth hormone signalling specifically, a cleaner releaser is worth more than a stronger one.
The corollary is that where maximum release is the objective and off-target activity is tolerable or is itself the subject, GHRP-2 or Hexarelin are the more appropriate choices. The Ipamorelin versus GHRP-2 comparison sets out where each is the better fit.
Because GHSR-1a and the GHRH receptor are distinct, agonists at the two are frequently combined to produce a larger response than either gives alone; that is what the CJC-1295 / Ipamorelin preparation is for. Literature is indexed on PubMed.
How Amino Club supplies it
Ipamorelin is supplied lyophilised in sealed vials as Ipamorelin, and within the combined CJC-1295 / Ipamorelin preparation. Each batch is specified at 99% purity or better by HPLC with identity confirmed by mass spectrometry and released against the Certificate of Analysis carrying the batch number printed on the vial. The lab testing page documents the release sequence.
The sequence contains two D-amino acids and a C-terminal amide, none of which are default outcomes of peptide synthesis, so identity confirmation is doing real work here rather than serving as a formality. Sealed vials tolerate ambient transit and are stored at -20°C long term; reconstitution notes sit on the product page and solvents under reconstitution supplies.
Related reading
Ipamorelin belongs to the growth and recovery group, alongside CJC-1295, MK-677, Sermorelin, Tesamorelin and IGF-1 LR3. Comparisons: Ipamorelin versus GHRP-2 and CJC-1295 with versus without DAC.
The research library indexes every guide here. Certificates and storage are covered on the FAQ; quantity pricing through bulk and wholesale.
Research use only
Ipamorelin supplied by Amino Club is a laboratory reference material. It is not a medicine, not a supplement, and not for human or veterinary use, and no dosing guidance or administration protocol is provided. The full terms are in the research use policy.