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Compound guide
Hexarelin: what the research covers
A hexapeptide secretagogue that binds two unrelated receptors. The second one, CD36, is why hexarelin has a cardiac literature that none of its siblings share.
What Hexarelin is
Hexarelin is His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2. The methyl group on the second tryptophan is the stability feature; the D-configuration residues and the terminal amide do the rest of the work of surviving in solution.
At GHSR-1a it is a potent agonist, comparable to GHRP-2 in the size of the growth hormone response it produces. It also desensitises quickly under continuous exposure, which is a property of the receptor rather than of this particular ligand, but hexarelin is where it was characterised most thoroughly.
Two receptors, two literatures
What sets hexarelin apart is that it binds CD36, a scavenger receptor expressed on cardiac myocytes, macrophages and endothelium, which has nothing to do with growth hormone. That second interaction produced a body of cardiovascular work — infarct models, myocardial protection, angiogenesis — in which the effects persist in animals lacking a functional growth hormone axis.
For an experimentalist this is both an opportunity and a trap. The opportunity is a single ligand that can be used to interrogate two unrelated pathways. The trap is attributing a cardiac observation to growth hormone release when CD36 is the more likely route, which is exactly why hexarelin studies so often include a selective secretagogue such as ipamorelin as a discriminating control.
How Amino Club supplies it
Hexarelin is supplied lyophilised in sealed vials as Hexarelin Acetate, specified at 99% purity or better by HPLC with identity confirmed by mass spectrometry and released against the Certificate of Analysis for its own batch. The lab testing page covers how that is tested.
The 2-methyl modification on tryptophan is the kind of detail that only mass spectrometry resolves, so identity confirmation is substantive here rather than procedural. Sealed vials tolerate ambient transit and are held below −18 °C for long-term storage; solvents are listed under reconstitution supplies.
Related reading
Hexarelin sits in the growth hormone research peptides group with GHRP-2, ipamorelin, MK-677 and the GHRH analogues sermorelin, CJC-1295 and tesamorelin.
Every guide is indexed in the research library. Certificates and storage are covered on the FAQ, quantity pricing through bulk and wholesale.
Research use only
Hexarelin supplied by Amino Club is a laboratory reference material. It is not a medicine, not a supplement, and not for human or veterinary use, and no dosing guidance or administration protocol is provided. The full terms are in the research use policy.