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Compound guide
ARA-290: what the research covers
An eleven-residue peptide taken from the inside of erythropoietin: the part that signals tissue protection, deliberately separated from the part that makes red blood cells.
What ARA-290 is
Erythropoietin does two unrelated things. One is familiar: it drives red blood cell production through the classical EPO receptor homodimer. The other is tissue protection, mediated by a different assembly — a heterocomplex of the EPO receptor with the common beta receptor, usually called the innate repair receptor.
The two activities map to different parts of the molecule. ARA-290 is an eleven amino acid sequence derived from helix B of erythropoietin, the face that engages the protective receptor, and it does not engage the erythropoietic one. The practical consequence is a compound that reproduces the tissue-protective arm of EPO signalling without raising haematocrit, which is what made the separation worth doing in the first place.
It is also known in the literature as cibinetide.
Why the receptor split is the whole story
For an experimentalist, ARA-290 is less interesting as a repair peptide than as a dissociation tool. If an effect of erythropoietin persists with ARA-290, that effect belongs to the innate repair receptor. If it disappears, it belonged to the classical receptor or to the haematological change downstream of it. Few compounds let a question be partitioned that cleanly.
Published work concentrates on neuropathic and small-fibre neuropathy models, on inflammatory signalling and macrophage phenotype, and on ischaemia-reperfusion injury in several tissues. There is also clinical trial literature, which is uncommon in this catalogue and which constrains the mechanism more tightly than cell work alone would.
Compared with the better-known repair peptides here — BPC-157 and TB-500, both of which act broadly and through mechanisms still under debate — ARA-290 has an unusually well-specified target.
How Amino Club supplies it
Supplied lyophilised in sealed vials as ARA-290, specified at 99% purity or better by HPLC with identity confirmed by mass spectrometry and released against the Certificate of Analysis for its own batch. The lab testing page documents the release sequence.
At eleven residues this is a short linear peptide and behaves like one: the dry powder is stable under ambient transit and stored below −18 °C long term, while solutions are prepared in small volumes, kept cold and dark, and not held indefinitely. Diluent options are under reconstitution supplies.
Related reading
ARA-290 sits in the tissue repair research peptides group with BPC-157, TB-500, KPV, LL-37 and VIP. The comparison BPC-157 versus TB-500 covers the two most studied members of that group.
Every guide is indexed in the research library. Certificates and storage are covered on the FAQ, quantity pricing through bulk and wholesale.
Research use only
ARA-290 supplied by Amino Club is a laboratory reference material. It is not a medicine, not a supplement, and not for human or veterinary use, and no dosing guidance or administration protocol is provided. The full terms are in the research use policy.