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Compound guide
CJC-1295: what the research covers
A modified GHRH analogue supplied in two forms whose half-lives differ by orders of magnitude. What CJC-1295 is, what the DAC changes, and how it is supplied.
What CJC-1295 is
CJC-1295 is a synthetic analogue of growth hormone releasing hormone, built on the first 29 residues of the natural sequence — the shortest fragment that retains full activity at the GHRH receptor. Four amino acid substitutions are made to that fragment, principally to resist cleavage by dipeptidyl peptidase-4, which degrades native GHRH within minutes.
It acts at the GHRH receptor on pituitary somatotrophs, amplifying the endogenous pulse rather than replacing it. That is the mechanistic difference between this class and recombinant HGH: the pituitary remains in the loop, and feedback regulation is preserved.
What the DAC changes
The two forms in the catalogue are the same core peptide. CJC-1295 with DAC carries a drug affinity complex — a maleimidopropionic acid group that forms a covalent bond with serum albumin after administration. Because albumin circulates with a half-life measured in weeks, the bound peptide persists far longer than the unmodified form, whose half-life is on the order of half an hour.
This is not a potency difference, it is a kinetic one, and it changes the shape of the experiment. The DAC form produces a sustained elevation; the form without DAC — often called modified GRF(1-29) — produces a discrete pulse that decays. Work concerned with pulsatility, or with pairing a GHRH analogue to a secretagogue so the two peaks coincide, requires the non-DAC form. The CJC-1295 with DAC versus without DAC comparison covers the implications in full.
Because GHRH analogues and ghrelin receptor agonists act at separate receptors, they are frequently combined; that is the basis of the CJC-1295 / Ipamorelin preparation. Literature is indexed on PubMed.
How Amino Club supplies it
Both forms are supplied lyophilised in sealed vials, alongside the combined CJC-1295 / Ipamorelin preparation. Each batch is specified at 99% purity or better by HPLC with mass spectrometric identity confirmation and released against the Certificate of Analysis carrying the batch number on the vial; the lab testing page documents the process.
Identity confirmation carries particular weight for this compound, because the two forms are close in mass and a laboratory that receives the wrong one will see a result that looks plausible and is not the experiment it designed. The mass spectrometric check is what separates them. Reconstitution notes are on each product page; solvents are under reconstitution supplies.
Related reading
CJC-1295 sits in the growth and recovery group with the ghrelin secretagogues Ipamorelin, GHRP-2 and MK-677, and the GHRH analogues Sermorelin and Tesamorelin. See also Ipamorelin versus GHRP-2.
Everything is indexed in the research library. Common questions are on the FAQ; institutional quantities through bulk and wholesale.
Research use only
CJC-1295 supplied by Amino Club is a laboratory reference material. It is not a medicine, not a supplement, and not for human or veterinary use, and no dosing guidance or administration protocol is provided. The full terms are in the research use policy.