The same 29-residue GHRH analogue as the non-DAC form, with one addition that stretches its half-life from half an hour to several days.
About CJC-1295 with DAC
This is a GHRH analogue built on the first 29 residues of growth hormone releasing hormone, with four substitutions that resist dipeptidyl peptidase-4 cleavage, plus a drug affinity complex: a maleimidopropionic acid group that forms a covalent bond with cysteine-34 on serum albumin.
Albumin circulates with a half-life of roughly twenty days, so the bound peptide persists far beyond what the sequence alone permits. The receptor target and binding affinity are unchanged from the non-DAC form — this is a pharmacokinetic modification, not a pharmacodynamic one.
What the research covers
The DAC form suits designs where sustained GHRH receptor occupancy is wanted and infrequent intervention is an advantage: multi-day or multi-week observation, downstream IGF-1 as an endpoint, and work on the consequences of flattening rather than amplifying the growth hormone pulse.
It is the wrong tool for pulsatility work, and it cannot be meaningfully paired with a short-acting secretagogue, because there is no peak to align a second peak to. The DAC versus non-DAC comparison sets out the trade-off, and the CJC-1295 guide covers the sequence. The growth hormone research peptides hub covers how this group splits between the two receptor families.
CJC-1295 with DAC specification
- Strengths available: 2mg, 5mg, 10mg
- Presentation: vial
- Purity: ≥99% by HPLC, identity confirmed by mass spectrometry
- Released against: the Certificate of Analysis for its own batch
Handling CJC-1295 with DAC
Supplied lyophilised. The maleimide group is the part that needs care: it is the reactive handle that forms the albumin bond, and it hydrolyses in aqueous solution, which is exactly the chemistry that makes this form what it is.
Solutions should therefore be prepared immediately before use rather than stored, because a hydrolysed maleimide leaves a peptide that no longer binds albumin and behaves as the non-DAC form instead — a silent conversion that will look like a kinetics result.
Solvent options are under reconstitution supplies.
Certificates, delivery and terms
This batch ships with the Certificate of Analysis carrying the batch number printed on its label; how that is tested and released is set out on the lab testing page. Delivery, customs and returns are covered on the shipping page, common questions on the FAQ, and quantity pricing through bulk and wholesale. Supplied for in-vitro laboratory research only: not a medicine, not a supplement, not for human or veterinary use, and no dosing or administration guidance is provided — see the research use policy.
